Goals supporting the Arabidopsis 2021 Roadmap: From bench to a bountiful harvest
A) Build a predictive model of an Arabidopsis plant from its molecular parts
B) Exploit the wealth of natural variation that exists in Arabidopsis to further our understanding of adaptation and evolution
C) Establish an effective knowledge exchange pipeline from the laboratory to the field and vice versa
D) Build the International Arabidopsis Informatics Consortium (IAIC), an international informatics and data infrastructure
E) Deepen International Cooperation and Coordination
- Build on large scale proteogenomic mapping efforts and integrative subcellular profiling to further enhance and expand current whole plant and subcellular protein expression maps in Arabidopsis
- Create a resource of validated Arabidopsis proteotypic peptides that can be employed for SRM-based quantitative analyses of proteins by mass spectrometry (e.g. AtSRM Atlas)
- Continue to expand and integrate new proteomics resources through the MASCP Gator
B) Exploit the wealth of natural variation that exists in Arabidopsis to further our understanding of adaptation and evolution
- Construct a 1001 proteomes portal for community exploitation and visualization of proteomes from Arabidopsis natural variants
- Undertake a coordinated proteomic analysis of Arabidopsis accessions to both validate genomics data and to identify specific SRM markers (based on nsSNPs) for specific proteins from accessions for future quantitative analyses
C) Establish an effective knowledge exchange pipeline from the laboratory to the field and vice versa
- Assist in the coordination proteomics activities in other plant systems through representations as the Arabidopsis committee on the International Plant Proteomics Organization (INPPO)
- Actively pursue proteomics research programs in other plant systems using key knowledge gained through the analysis of Arabidopsis
D) Build the International Arabidopsis Informatics Consortium (IAIC), an international informatics and data infrastructure
- Maintain and enhance existing informatics infrastructure in Arabidopsis proteomics
- Create new resources to exploit emerging technologies (e.g. AtSRM Atlas)
- Develop international proteomics standards in coordination with the iMOP program
- Continue to coordinate the integration of Arabidopsis proteomics resources through the MASCP Gator
- Integrate proteomics data resources with other informatics resources in Arabidopsis
E) Deepen International Cooperation and Coordination
- Represent Arabidopsis proteomics activities and develop proteomics standards through interactions with the initiative on Model Organism Proteomes program (iMOP) as part of the Human Proteome Organization (HUPO)
- Represent Arabidopsis proteomics interests as representatives of the International Plant Proteomics Organization (INPPO)
- Continue to offer proteomics workshops at international conferences